Date: 07/14/2015

Advanced Pediatric Therapeutics (APT) is organized by pharmacy practice setting with major sections dedicated to the Neonatal Intensive Care Unit (NICU), Pediatric Intensive Care Unit (PICU), Inpatient and Outpatient general practice, and Hematology/Oncology practice. APT is written for the advanced level practitioner with the assumption that the reader has a general/basic understanding of the disease state and common treatments. The primary focus is advanced management techniques, emerging research, and clinical controversies for each disease state. Each chapter incorporates a patient case and assessment questions.

​APT is not recommended as review material for BCPPS exam. Please refer to the Pediatric PharmPrep Advanced Guide for home-based BCPPS review materials. 

Editors:
Lea Eiland, PharmD, BCPS, FASHP, FPPAG
Timothy Todd, PharmD, FPPAG

Table of Contents 

Section 1: Neonatal Intensive Care Unit

Chapter 1: Pulmonary Hypertension in the Neonate
Kirsten H. Ohler, PharmD, BCPS

Chapter 2: Patent Ductus Arteriosus
Amy L. Potts, PharmD, BCPS

Chapter 3: Necrotizing Enterocolitis
Sherry Luedtke, PharmD, FPPAG

Chapter 4: Neonatal Infections
Christopher McPherson, PharmD

Chapter 5: Pain and Sedation in Preterm Infants
Christopher McPherson, PharmD

Chapter 6: Neonatal Abstinence Syndrome
Anita Siu, PharmD

Chapter 7: Hypoxic-Ischemic Encephalopathy in Newborns
Peter Gal, BS Pharm, PharmD, BCPS, FCCP, FASHP, FPPAG

Chapter 8: Neonatal Seizures
Peter Gal, BS Pharm, PharmD, BCPS, FCCP, FASHP, FPPAG

Chapter 9: Neonatal Nutrition
Kathleen M. Gura, PharmD, BCNSP, FASHP, FPPAG

Chapter 10: Apnea of Prematurity
Teresa D Puthoff, BS Pharm, PharmD

Chapter 11: Surfactant Replacement Therapy
Sandra S. Garner, BS, PharmD, BCPS, FCCP and Toby Hoffman Cox, BS, PharmD, BCPS

Chapter 12: Bronchopulmonary Dysplasia
Dawn R. Butler, PharmD

Section 2: Pediatric Intensive Care Unit

Chapter 13: Pediatric Resuscitation
Marcia L. Buck, PharmD, FCCP, FPPAG

Chapter 14: Congenital Heart Disease
David S. Hoff, PharmD, FCCP, Polina Gerber Lipnik, PharmD and Jennifer Lissick, PharmD, BCPS

Chapter 15: Extracorporeal Membrane Oxygenation
Brady S. Moffett, PharmD, MPH

Chapter 16: Pediatric Pulmonary Hypertension
Kirsten H. Ohler, PharmD, BCPS

Chapter 17: Diabetic Ketoacidosis
Jared J. Cash, BS, PharmD, BCPS and Brent A. Kay, PharmD

Chapter 18: Sepsis and Meningitis
Kim W. Benner, PharmD, BCPS, FASHP, FPPAG

Chapter 19: Status Epilepticus
Stephanie J. Phelps, BSPharm, PharmD, BCPS, FAPhA, FCCP, FPPAG and Elizabeth L. Alford, PharmD

Chapter 20: Pain and Sedation 
Peter N. Johnson, PharmD, BCPS

Chapter 21: Acute Asthma 
Lisa Lubsch, PharmD, AE-C

Chapter 22: Transplant
Krisha Le Palma, PharmD

Chapter 23: Trauma
Joseph M. LaRochelle, PharmD

Chapter 24: Toxicology
Shannon F. Manzi, PharmD, NREMT

Section 3: General Pediatrics

Chapter 25: Kawasaki Disease
Kristin C. Klein, PharmD, FPPAG

Chapter 26: Pediatric Hypertension
Regine L. Caruthers, PharmD and E. Zachary Ramsey, PharmD

Chapter 27: Atopic Dermatitis
Catherine M. Tom-Revzon, BS, PharmD

Chapter 28: Inflammatory Bowel Disease
Darcie D. Streetman, PharmD

Chapter 29: Diabetes Mellitus
Susan Cornell, BS, PharmD, CDE, FAPhA, FAADE

Chapter 30: Antimicrobial Controversies in Children
Heather L. Girand, PharmD

Chapter 31: Bronchiolitis
Lea S. Eiland, PharmD, BCPS, FASHP, FPPAG

Chapter 32: Skin/Soft Tissue, Bone, and Joint Infections
Jennifer E Girotto, PharmD

Chapter 33: Human Immunodeficiency Virus
Ashley S. Crumby, PharmD, AAHIVP

Chapter 34: Immunization Controversies in Children
Leslie A Briars, PharmD

Chapter 35: Attention Deficit/Hyperactivity Disorder
Amanda W. Williams, PharmD, BCPS, Mary A. Worthington, PharmD, BCPS and Marshall E. Cates, PharmD, BCPP, FASHP

Chapter 36: Autism Spectrum Disorder
Julie A. Dopheide, PharmD, BCPP

Chapter 37: Depression
Timothy J. Todd, PharmD, FPPAG and Jennifer L. Mazan, PharmD

Chapter 38: Cerebral Palsy
Cassie A. Billings, BS, PharmD

Chapter 39: Cystic Fibrosis
Kimberly J. Novak, PharmD, BCPS

Chapter 40: Chronic Asthma
Lisa Lubsch, PharmD, AE-C

Chapter 41: Pediatric Palliative Care
Tracy M. Hagemann, PharmD, FCCP, FPPAG

Section 4: Hematology/Oncology

Chapter 42: Chemotherapy Dosing Controversies
David W. Henry, MS, BCOP, FASHP

Chapter 43: Central Nervous System Tumors
Nancy Heideman, PharmD, BCPS and Richard L. Heideman, MD

Chapter 44: Pediatric Leukemia and Lymphoma
Susannah E. Koontz, PharmD, BCOP

Chapter 45: Solid Tumors
M. Brooke Bernhardt, PharmD, MS, BCOP

Chapter 46: Adolescents and Young Adults with Cancer
Kerry Parsons, BS, PharmD, BCOP

Chapter 47: Chemotherapy-Induced Nausea and Vomiting
Betsy Bickert Poon, PharmD, FCCP

Chapter 48: Supportive Care in Pediatric Oncology
Alix A. Dabb, PharmD

Chapter 49: Fungal Infections
Katie Namtu, PharmD

Chapter 50: Hematopoietic Cell Transplantation Complications
Melisa K. Stricherz, PharmD, BCOP and Cathryn A. Jennissen, PharmD, BCOP

Chapter 51: Anticoagulation
Emily Scarbrough Waite, PharmD, BCOP

Chapter 52: Sickle Cell Disease
Lori Y. Chen, BScPhm, ACPR and Sabrina Boodhan, HonBSc, BSPhm, ACPR and James Tjon, BSPhm, PharmD

Chapter Reviewers

Kelly S. Bobo, PharmD, BCPS
William Brown, PharmD, MBA
Katherine H. Chessman, BS-Pharm, PharmD, BCPS, BCNSP, FPPAG, FCCP
Jennifer W. Chow, PharmD
Michael L. Christensen, PharmD, BCNSP, FPPAG
Jeffrey J. Cies, PharmD, MPH, BCPS-AQ ID
Mary Petrea Cober, PharmD, BCNSP
Michelle E. Condren, PharmD, AE-C, CDE
Jason Corcoran, PharmD, BCPS
Shane J. Cross, PharmD
Cynthia M. Dusik, RPh, PharmD
Helen Beckman Fiechtner, BS, PharmD, FPPAG
David Frame, BS
Matthew Gentry, PharmD
Peter Gal, BS Pharm, PharmD, BCPS, FCCP, FASHP, FPPAG
Kathleen M. Gura, PharmD, BCNSP, FASHP, FPPAG
Sally K. Guthrie, PharmD, BCPP, FCCP
Mark R. Haase, PharmD, BCPS, FCCP
Shirley M. Hogan, PharmD
Jessica L. Jacobson, PharmD, BCPS
Rebecca H. Johnson, MD
Donna M. Kraus, PharmD, FAPhA, FCCP, FPPAG
Kay Kyllonen, PharmD, FPPAG
Rachel C. Langley, PharmD
Cheryl A. Laubacher, BS, PharmD, BCACP
Bernard R Lee, PharmD, BCPS
Carlton K.K. Lee, PharmD, MPH, FASHP, FPPAG
Deborah A. Maka, PharmD
Kalen B. Manasco, PharmD, BCPS, AE-C
Jamie L. Miller, PharmD, BCPS
Kevin M. Mulieri, BS, PharmD
Charla Miller Nowak, BS Pharm, PharmD
Andrew Ostrenga, PharmD
Jennifer T Pham, PharmD, BCPS
Robert L. Poole, PharmD, FPPAG, FCSHP, FASHP
Teresa D Puthoff, BS Pharm PharmD
Leslie Raffini, MD, MSCE
Jennifer M. Raltz, PharmD
Michael D. Reed, PharmD, FCCP, FCP
Chasity M. Shelton, PharmD, BCPS, BCNSP
Kimberly Tallian, PharmD, BCPP, FASHP, FCCP, FCSHP
Deborah A. Ward, BS, PharmD, BCOP, BCPS